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Note: This only includes people who have Public Search Listings available on … We investigated if serum from diabetic patients treated with glargine versus human insulin may display a similar effect. Und dann muss auch noch der wunderbar singende Ehemann MAX HOPP mit ran :) 31.05.2017. In livers of rats and mice DHEA increases the levels of cytochrome P450 IVA and peroxisomal beta-oxidation enzymes associated with peroxisome proliferation. Knockdown of β-catenin by RNAi resulted in significant reduction of...The 3rd International Workshop on Insulin & Cancer was held on October 30-31, 2010 at the German Cancer Research Centre in Heidelberg/Germany.

In cross-over fashion, 23 patients were treated...Estrogens are suggested to play a role in the development and progression of proliferative diseases such as breast cancer. All rights reserved. The biological actions of the IGFs are mediated by the IGF-I receptor (IGF-IR), a cell-surface tyrosine kinase, whose activation by serum IGF-I seems to be a key step in breast cancer initiation. Doris Mayer was head of the Hormones and Signal Transduction Group, German Cancer Research Center. an increase in peroxisomes mainly in perivenular parts of the liver lobule. CCHCC is composed of mixtures of clear and/or acidophilic ground glass hepatocytes with excessive glycogen and/or fat and shares histology, clinical features and...Zinc signaling is mediated by the zinc sensing receptor, ZnR, recently suggested to be the same receptor as G-protein coupled receptor 39, GPR39.
In previous investigations on experimentally induced rat hepatomas, we detected aldose reductase-like protein (ARLP) as a highly significant marker protein.


Förderung seit 2017Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 328283147 Parcourez la liste de vos amis par ordre alphabétique. Moreover, DHEA modulates preneoplastic liver foci of the glycogenotic/basophilic cell line...Insulin receptor substrate-1 (IRS-1) is over-expressed in preneoplastic glycogenotic hepatic foci (GSF) and is gradually down-regulated during progression of these lesions, via mixed cell foci (MCF), to the basophilic neoplastic phenotype. We investigated the expression pattern of insulin-like growth factor-I receptor (IGF-IR), insulin receptor (IR) and insulin receptor substrate-1 (IRS-1), a core downstream signaling protein, in...The ligands, receptors and related signaling proteins of the insulin-like growth factor family are involved in the regulation of breast-cancer cell growth. Nine benign or malignant human mammary epithelial cells, which show different insulin receptor and IGF-I...The insulin-like growth factors (IGFs) play a pivotal role in breast cancer. In this report we show by mutational analysis and in vitro kinase assays that ERα is a subst...S100 proteins comprise a family of calcium-modulated proteins that have recently been associated with epithelial tumors. To evaluate the impact of BRCA1 mutations on IGF-IR gene expression, we performed an immunohistochemical analysis of IGF-IR in primary breast tumors from BRCA1 mutation...Glycogen synthase kinase-3 (GSK-3) plays a key role in the regulation of transcription factors including steroid receptors. Having identified estrogen receptor-alpha (ERalpha) as substrate for GSK-3, the impact of GSK-3 on ERalpha function and activity upon 17beta-estradiol (E2)-dependent activation remains to be clarified. However, more recent biochemical and molecular biological approaches in situ provided compelling evidence for an essential role of early changes in energy metabo...Biochemical and molecular biological approaches in situ have provided compelling evidence for early bioenergetic changes in hepatocarcinogenesis.