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Jetzt aber zeigt eine neue Studie, wie der Wirkstoff ein mutiertes Protein, das in mehr als der Hälfte aller Brustkrebsfälle vorhanden ist, von der Aggregation abhalten kann. Some research shows that resveratrol could be linked to a lower risk of inflammation and blood clotting, which can lower your risk of heart disease. Unable to load your collection due to an error Some of the reported DDS present advantageous characteristics, such as enhanced stability, bioavailability, and biocompatibility. This barrier consists on a monolayer of capillary endothelial cells that block the path of over 98% of small-molecule drugs and 100% of large-molecule (>500 Da) (The capability of nanosystems to cross the BBB depends on their physicochemical properties, and therefore nanocarriers must meet several requirements as being non-toxic, able to carry the desired drug and able to interact with receptors present at the BBB (As mentioned above, a growing number of studies have focused on the treatment of several neurological diseases with RES encapsulated in NPs. 2020 Apr;467(1-2):57-64. doi: 10.1007/s11010-020-03700-2.
Studies proved that RES activates these proteins, stimulating the Aβ clearance. Wiley RES was found to suppress NF-κB factor activation by hampering the nuclear translocation of its p65 subunit, leading to a downregulation on the expression of uPA/uPAR genes reducing the glioma cell invasion (Programmed cell death – apoptosis – causes cell changes, as cell shrinkage, loss of cell membrane integrity, and DNA fragmentation causing the cellular death. Resveratrol and pterostilbene, the polyphenol found in grape and blueberries, have beneficial effects as anti-aging compounds through modulating the hallmarks of aging, including oxidative damage, inflammation, telomere attrition and cell senescence. An Aβ monomers with α-helix conformation are produced by the sequential action of β- and γ-secretases responsible for the proteolytic cleavage of amyloid precursor protein. View all However, studies on resveratrol are mixed.

Also, the majority of the NPs have high stability and loading capacity. The neuroprotective effects of RES in neurological diseases, such as Alzheimer’s (AD) and Parkinson’s (PD) diseases, are related to the protection of neurons against oxidative damage and toxicity, and to the prevention of apoptotic neuronal death. © 2017 BioFactors, 44(1):69-82, 2018. Resveratrol is a non-flavonoid polyphenolic compound that was first identified in extracts from the white hellebore Veratrum grandiflorum. 3 RES has been encapsulated in many different types of nanosystems, as liposomes, lipid and polymeric NPs. 2018 Jan;44(1):36-49. doi: 10.1002/biof.1399. Resveratrol is a natural phenol, released by certain plants in response to attack or injury. However, its high proliferation rate and invasiveness contributes to its high resistance to therapy (Resveratrol chemopreventive activity in leukemia cells was reported for the first time in Several molecules are involved in the carcinogenesis and progression of brain tumors and can be envisaged as therapeutic targets for RES. eCollection 2020.Mol Cell Biochem.

2020 Feb 6;11:63. doi: 10.3389/fphys.2020.00063. The malignancy and recurrence of glioma tumors is affected by the signaling pathway of STAT3, that is extensively activated by phosphorylation in brain tumors (The invasiveness and malignancy degree of glioma tumors is related with an aberrant neovascularization and the cellular invasion of adjacent tissues. The drug pharmacokinetics is affected by the physicochemical properties of the NPs, conditioning their bioavailability and biodistribution. However, its biopharmaceutical and pharmacokinetic issues limit its use as a therapeutic agent. Xin colleagues proposed for the first time the encapsulation of RES in a nanosystem envisaged for glioma therapy and diagnostic simultaneous application. The first-line treatment of glioma tumors is based on a multimodal approach combining tumor resection with surgery, chemotherapy and radiotherapy. The death of dopaminergic neurons within the The use of therapeutic molecules to decrease the amount of apoptotic dopaminergic neurons and reduce the oxidative stress in the Mitochondrial complex I is appointed as one of the main causes of ROS production (Diminution of mitochondrial dysfunction with specific antioxidants, such as RES, has been proved to be effective in Despite the efforts to develop a new therapy for PD, the available therapies only attenuate the symptoms. Several approaches have been studied in the last years to delivery RES to the brain. All the authors contributed with the bibliographic research.This work was the result of the project POCI-01-0145-FEDER-006939 (Laboratory for Process Engineering, Environment, Biotechnology and Energy – UID/EQU/00511/2013) funded by the European Regional Development Fund (ERDF), through COMPETE2020 – Programa Operacional Competitividade e Internacionalizção (POCI) and by national funds, through FCT – Fundção para a Ciência e a Tecnologia; and NORTE-01-0145-FEDER-000005 – LEPABE-2 ECO-INNOVATION, supported by North Portugal Regional Operational Program (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF); and FCT doctoral grants (PD/BD/105984/2014 and SFRH/BD/129312/2017).The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.